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Botox Injection Techniques and Dosage Summary (Glabellar Wrinkles - Corrugator Supercilii, Procerus) Botulax vs Botox vs Xeomin

  • Writer: Medihealkorea
    Medihealkorea
  • Mar 6
  • 3 min read

Updated: Mar 11


Mesotherapy: A cosmetic treatment involving microinjections of vitamins, enzymes, or other substances to rejuvenate and tighten the skin.
Mesotherapy: A cosmetic treatment involving microinjections of vitamins, enzymes, or other substances to rejuvenate and tighten the skin.

Glabellar wrinkles are primarily caused by the corrugator supercilii and procerus muscles. Therefore, Botox injections should be administered in a way that inhibits the movement of these muscles.

 

1. Injection Sites and Techniques

Botox injection methods for the glabellar area vary depending on the muscle structure and wrinkle pattern. 

Indicates the injection sites of Botox according to the shape of the wrinkles.
Indicates the injection sites of Botox according to the shape of the wrinkles.

✅ Corrugator Supercilii Injection Sites

  • Wrinkle Type: Deep vertical wrinkles that form when frowning


Injection sites for the V-shaped eyebrow wrinkle muscle.
Injection sites for the V-shaped eyebrow wrinkle muscle.

  • Injection Points:

    • Central (medial) injection: Approximately 0.5 cm above the inner corner of the eyebrow in the middle of the glabella. Injection depth: 8mm (¾ needle length)

    • Lateral injection: In the concave area of the skin near the outer end of the eyebrow. Injection depth: 2-4mm (¼ needle length)

    • Precautions: Do not inject 0.5-1cm beyond the outer eyebrow edge, as improper injection can lead to brow ptosis or eyelid ptosis.

✅ Procerus Injection Sites

  • Wrinkle Type: Horizontal wrinkles (formed when making an angry expression)


Injection site for the eyebrow wrinkle muscle positioned horizontally
Injection site for the eyebrow wrinkle muscle positioned horizontally

  • Injection Points:

    • Single central injection: Middle of the glabella, directly between the eyebrows

    • Depth: Approximately 6mm (½ needle length)

    • Dosage: 4-6U per injection site

✅ V-Shaped Corrugator Supercilii Injection

  • Adjust the injection depth based on the V-shaped muscle structure: inject deeper in the inner area and shallower in the outer area.

Injection site for the eyebrow wrinkle muscle positioned in a V-shape
Injection site for the eyebrow wrinkle muscle positioned in a V-shape
Injection site for the eyebrow wrinkle muscle positioned in a V-shape
Injection site for the eyebrow wrinkle muscle positioned in a V-shape

  • Dosage:

    • Deep medial part: 4-6U

    • Shallow lateral part: 2-4U

 

2. Botox Dosage Guidelines

Muscle

Injection Site

Dosage (U, Botox standard)

Procerus

Central single point

4-6U

Corrugator Supercilii

Medial (deep)

4-6U

Corrugator Supercilii

Lateral (shallow)

2-4U

Average dosage for men

-

24U / 60 sU

Average dosage for women

-

24U / 50 sU

✅ Gender Differences

  • Men have a longer and stronger corrugator supercilii muscle, so they require a higher dosage compared to women.

 

3. Recommended Syringe and Injection Depth


  • Botox dilution ratio: 1mL saline + 100U Botox

  • Needle type: 30G (commonly used for glabellar Botox injections)

  • Depth adjustments:

    • Superficial areas (lateral corrugator) → 2-4mm depth

    • Thicker muscle areas (medial corrugator) → 6-8mm depth

 

4. Botox Duration and Treatment Frequency


  • Onset of effect: Typically 2-7 days after injection

  • Duration: Average of 3-4 months

  • Treatment interval: Repeat every 4-6 months

  • Higher dosage use: Can extend the duration up to 6 months

 

5. Comparison of Botulinum Toxin Types (Botox, Xeomin, Botulax)


Product

Key Features

Dilution Ratio

Onset of Effect

Duration

Botox (OnabotulinumtoxinA)

Most extensively researched, strong neural transmission blocking effect

2.5mL:100U

3~5 days

3~4 months

Xeomin (IncobotulinumtoxinA)

Purified toxin without complexing proteins, lower risk of antibody formation

2.5mL:100U

Faster (2~3 days)

3~4 months

Botulax

Korean-made toxin, relatively lower cost

2.5mL:100U

3~5 days

3~4 months

  • Xeomin has a faster onset of effect compared to Botox and carries a lower risk of antibody formation, making it advantageous in some cases.


 

6. Post-Injection Care Instructions


To maximize the effectiveness of Botox and minimize side effects, follow these care instructions:

✅ Do not lie down for 4 hours after injection

  • Prevents Botox from spreading to unintended areas

✅ Avoid rubbing the forehead

  • Massage or strong pressure can cause Botox to spread

✅ Avoid intense exercise for 24 hours

  • Increased body temperature can reduce Botox efficacy


 

7. Potential Side Effects of Botox Injection


While Botox is generally safe, some side effects may occur:

❗ Brow or Eyelid Drooping (Brow Ptosis, Eyelid Ptosis)

  • Caused by injecting too far beyond the eyebrow or too deep

❗ Bruising and Bleeding

  • The glabellar area has many blood vessels, so bruising may occur

❗ Asymmetry

  • If the injection dosage differs between sides, the eyebrow height may appear uneven


 

8. Conclusion


Botox injections for glabellar wrinkles require a precise understanding of muscle anatomy and customized dosing based on the patient’s wrinkle pattern.

  • Men may require a higher dosage due to stronger muscles.

  • Injection depth and angle should be carefully adjusted to minimize the risk of side effects such as eyelid drooping.

By following these guidelines, you can achieve a natural and effective reduction in glabellar wrinkles. Always consult with a qualified professional for the best results!



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